• Zhe Wang, Shushu Sun, Kunming Xie, and Junjie Miao.
• Department of Neurosurgery, Weifang People's Hospital, Weifang, China.
• Medicine (Baltimore). 2023 Jan 6; 102 (1): e32616e32616.

RationaleMeningioma and glioblastoma (GBM) are 2 common intracranial tumors with different pathophysiologies and prognoses. It is rare for these 2 kinds of tumors to occur in the same patient. Most of the similar cases reported in the literature have been treated with radiotherapy, while cases without radiotherapy are rare. In particular, GBM in the contralateral cerebral hemisphere after resection of meningioma has not been reported.Patient ConcernsWe present a case of a 66-years-old man with GBM in the right temporal lobe after previous resection of a benign meningioma of the left frontal lobe without radiotherapy.DiagnosesThe patient was admitted to our hospital for the first time because of right upper limb weakness. Brain magnetic resonance imaging indicated a space-occupying lesion in the left frontal area. Surgical treatment was performed, and postoperative pathology confirmed a meningioma. The patient was readmitted to the hospital 3 years after surgery of the meningioma due to a new lesion of the right temporal lobe and underwent reoperation. The postoperative pathological results showed GBM.InterventionsThe patient underwent 2 operations, and the postoperative pathologies were meningioma and GBM. In addition, the patient received concurrent chemoradiotherapy and 2 cycles of temozolomide adjuvant chemotherapy.OutcomesDuring the last 4 months of follow-up, the patient was in good condition with no recurrence of the tumor.LessonsThe development of GBM without radiotherapy after meningioma surgery is very rare, especially at different sites, and it is necessary to accumulate relevant cases to reveal the causes of the disease and provide more evidence for the treatment of similar patients in the future.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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