• S Adnot, D Bernard, L Lipskaia, and F Trottein.
• Inserm U955 et département de physiologie, hôpital Henri-Mondor, AP-HP, FHU- SENEC, université Paris-Est Créteil (UPEC), 94010 Créteil, France.
• B Acad Nat Med Paris. 2023 Feb 1; 207 (2): 193198193-198.

AbstractThe accumulation of senescent cells in tissues is a key process of aging and age-related diseases, including lung diseases such as chronic obstructive pulmonary disease, lung fibrosis, or cancer. In recent years, the spectrum of respiratory diseases associated with cellular senescence has been broadened, in particular acute viral pulmonary infections, foremost among which is coronavirus disease 2019 (COVID19), which is particularly severe in the elderly or in subjects with comorbidities. Influenza virus infection, which strikes more severely at the extreme ages of life, is also associated with severe pulmonary senescence. Cellular senescence potentially represents an original target for attacking these diseases, although its specific mechanisms remain largely misunderstood. New anti-senescent therapeutic approaches are thus proposed during severe viral pulmonary infections, with the aim of preventing acute effects and/or, in the longer term, pulmonary sequelae.© 2022 l'Académie nationale de médecine. Published by Elsevier Masson SAS. All rights reserved.

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