• Yajing Wang, Ganggang Si, Xiangbing Li, Jianjun Li, Ruxia Zhang, and Sancong Pan.
• Department of Cardiology, Jincheng People's Hospital, Jincheng, China.
• Medicine (Baltimore). 2023 Jan 13; 102 (2): e32656e32656.

RationaleCoronary artery spasm (CAS) defined by severe reversible focal or diffuse vasoconstriction, plays an essential role in the pathophysiology of acute coronary syndrome but is not very common in the clinic. Due to its transience, it is difficult to diagnose CAS directly, many patients are diagnosed by clinical experience. Here, we report the diagnosis and treatment of a rare case of simultaneous total occlusion due to spasm of the two main coronary arteries by coronary angiography (CAG).Patient ConcernsA 47-year-old man with no medical history was admitted to our emergency room complaining of sudden-onset chest pain lasting 3 hours. Emergency CAG showed total occlusion of the proximal left anterior descending artery and right coronary artery.DiagnosesAcute myocardial infarction caused by CAS was diagnosed, according to CAG findings and test results.InterventionsIntracoronary injection of nitroglycerin and anti-spasm medication.OutcomesThe patient was discharged on the 8th day with complete resolution of symptoms and normalization of the electrocardiography findings. No ischemic events occurred during a follow-up for 27 months.LessonsThis case highlights the significance of identifying CAS in patients with acute myocardial infarction and avoiding blind interventional stent therapy, which requires closer attention from clinicians.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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