• Joaquín Cantos, Iván A Huespe, Jorge F Sinner, Eduardo M Prado, Eduardo San Roman, RolónNicolás ContreraNCCritical Care Department, Hospital Italiano de Buenos Aires, Argentina; Nephrology Department, Hospital Italiano de Buenos Aires, Argentina., and Carlos G Musso.
• Critical Care Department, Hospital Italiano de Buenos Aires, Argentina. Electronic address: joaquin.cantos@hospitalitaliano.org.ar.
• J Crit Care. 2023 Apr 1; 74: 154248154248.

PurposeAlactic base excess (ABE) is a novel biomarker defined as the sum of lactate and standard base excess and estimates the renal capability of handling acid-base disturbances in sepsis. The objective of this study is to see if ABE is an independent predictor of mortality in septic patients with and without renal dysfunction.Materials And MethodsWe retrospectively studied 1178 patients with sepsis and septic shock. Patients were divided according to ABE values: 1) negative ABE (<-3 mmol/L); 2) neutral ABE (≥ - 3 and < 4 mmol/L); and 3) positive ABE (≥4 mmol/L). The effect of ABE on mortality was evaluated using Cox regression weight by inverse probability weighting (IPWT) analysis after propensity score assessment. Additionally, we performed a stratified analysis in patients with GFR > 60 mL/min/1.73 m2.ResultsNegative ABE patients had higher mortality than patients with neutral ABE (adjusted HR 1.43; 95%CI 1.02-2.01). Also, in patients with GFR > 60 mL/min/1.73 m2 (n = 493), we observed higher mortality in patients with negative ABE (adjusted HR 2.43; 95%CI 1.07-5.53).ConclusionsNegative ABE is an independent predictor of in-hospital mortality in septic patients with and without renal dysfunction.Copyright © 2023 Elsevier Inc. All rights reserved.

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