• Ashwin Sankar, Kevin Thorpe, Daniel I McIsaac, Jin Luo, Duminda N Wijeysundera, and Andrea S Gershon.
• Department of Anesthesia (Sankar, Wijeysundera), Unity Health Toronto, St. Michael's Hospital; Department of Anesthesiology and Pain Medicine (Sankar, Wijeysundera), University of Toronto; ICES Central (Sankar, McIsaac, Luo, Wijeysundera, Gershon); Li Ka Shing Knowledge Institute of St. Michael's Hospital (Sankar, Wijeysundera); Dalla Lana School of Public Health (Thorpe, Gershon), University of Toronto; Applied Health Research Centre (AHRC) (Thorpe), Toronto, Ont.; Department of Anesthesiology and Pain Medicine (McIsaac), University of Ottawa; Department of Anesthesiology and Pain Medicine (McIsaac), The Ottawa Hospital; Ottawa Hospital Research Institute (McIsaac), Ottawa, Ont.; Division of Respirology, Department of Medicine (Gershon), University of Toronto; Division of Respirology, Department of Medicine (Gershon), Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont. ashwin.sankar@mail.utoronto.ca.
• CMAJ. 2023 Jan 17; 195 (2): E62E71E62-E71.

BackgroundChronic obstructive pulmonary disease (COPD) is common among surgical patients, and patients with COPD have higher risk for complications and death within 30 days after surgery. We sought to describe the longer-term postoperative survival and costs of patients with COPD compared with those without COPD within 1 year after inpatient elective surgery.MethodsIn this retrospective population-based cohort study, we used linked health administrative databases to identify all patients undergoing inpatient elective surgery in Ontario, Canada, from 2005 to 2019. We ascertained COPD status using validated definitions. We followed participants for 1 year after surgery to evaluate survival and costs to the health system. We quantified the association of COPD with survival (Cox proportional hazards models) and costs (linear regression model with log-transformed costs) with partial adjustment (for sociodemographic factors and procedure type) and full adjustment (also adjusting for comorbidities). We assessed for effect modification by frailty, cancer and procedure type.ResultsWe included 932 616 patients, of whom 170 482 (18%) had COPD. With respect to association with risk of death, COPD had a partially adjusted hazard ratio (HR) of 1.61 (95% confidence interval [CI] 1.58-1.64), and a fully adjusted HR of 1.26 (95% CI 1.24-1.29). With respect to impact on health system costs, COPD was associated with a partially adjusted relative increase of 13.1% (95% CI 12.7%-13.4%), and an increase of 4.6% (95% CI 4.3%-5.0%) with full adjustment. Frailty, cancer and procedure type (such as orthopedic and lower abdominal surgery) modified the association between COPD and outcomes.InterpretationPatients with COPD have decreased survival and increased costs in the year after surgery. Frailty, cancer and the type of surgical procedure modified associations between COPD and outcomes, and must be considered when risk-stratifying surgical patients with COPD.© 2023 CMA Impact Inc. or its licensors.

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