• Internal medicine · Sep 2023

    Case Reports

    Focal Segmental Sclerosis Associated with the Novel Multi-tyrosine Kinase Inhibitor Ponatinib: A Case Report.

    • Hiroyuki Arai, Shinya Yamamoto, Takeshi Matsubara, Takafumi Miyake, Akira Tochio, Akiko Mii, Akira Shimizu, Sachiko Minamiguchi, Eri Muso, and Motoko Yanagita.
    • Department of Nephrology, Kyoto University Graduate School of Medicine, Japan.
    • Intern. Med. 2023 Sep 15; 62 (18): 269326982693-2698.

    AbstractPonatinib is a novel multi-tyrosine kinase inhibitor (TKI) with potent inhibitory activity against refractory chronic myeloid leukemia (CML). Despite its high clinical efficacy, ponatinib induces various adverse events due to its multi-target characteristic. However, renal complications associated with ponatinib are rare. A 76-year-old woman had a history of chronic myeloid leukemia (CML) resistant to imatinib and nilotinib. Our patient developed proteinuria and renal function deterioration during treatment with ponatinib but not with imatinib or nilotinib. We herein report the first case of a patient with secondary focal segmental glomerulosclerosis (FSGS) with partial glomerular collapse induced by ponatinib treatment.

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