• Sheila Nainan Myatra, Waleed Alhazzani, Emilie Belley-Cote, MøllerMorten HylanderMH0000-0002-6378-9673Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Yaseen M Arabi, Rajesh Chawla, Michelle S Chew, Sharon Einav, Begum Ergan, Maj-Brit Nørregaard Kjaer, Steve McGloughlin, Prashant Nasa, Ken Kuljit S Parhar, Anil Patel, Lise Piquilloud, Lara Pisani, Raffaele Scala, Swagata Tripathy, Jason Weatherald, and Simon Oczkowski.
• Department of Anesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.
• Acta Anaesthesiol Scand. 2023 May 1; 67 (5): 569575569-575.

AbstractThis rapid practice guideline provides evidence-based recommendations for the use of awake proning in adult patients with acute hypoxemic respiratory failure due to COVID-19. The panel included 20 experts from 12 countries, including one patient representative, and used a strict conflict of interest policy for potential financial and intellectual conflicts of interest. Methodological support was provided by the guidelines in intensive care, development, and evaluation (GUIDE) group. Based on an updated systematic review, and the grading of recommendations, assessment, development, and evaluation (GRADE) method we evaluated the certainty of evidence and developed recommendations using the Evidence-to-Decision framework. We conducted an electronic vote, requiring >80% agreement amongst the panel for a recommendation to be adopted. The panel made a strong recommendation for a trial of awake proning in adult patients with COVID-19 related hypoxemic acute respiratory failure who are not invasively ventilated. Awake proning appears to reduce the risk of tracheal intubation, although it may not reduce mortality. The panel judged that most patients would want a trial of awake proning, although this may not be feasible in some patients and some patients may not tolerate it. However, given the high risk of clinical deterioration amongst these patients, awake proning should be conducted in an area where patients can be monitored by staff experienced in rapidly detecting and managing clinical deterioration. This RPG panel recommends a trial of awake prone positioning in patients with acute hypoxemic respiratory failure due to COVID-19.© 2023 Acta Anaesthesiologica Scandinavica Foundation.

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