• Medicina clinica · Apr 2023

    Observational Study

    Persistent olfactory dysfunction in mild COVID-19 patients: A descriptive study of the characteristics and association with other symptoms.

    • David Dylan García-Meléndez, María Isabel Morales-Casado, Pilar Quintana Castro, and Carlos Marsal Alonso.
    • Hospital Universitario de Toledo, Av. Río Guadiana, 45007 Toledo, Spain.
    • Med Clin (Barc). 2023 Apr 21; 160 (8): 347351347-351.

    IntroductionPost-COVID olfactory dysfunction continues to be studied due to the controversy of the mechanisms involved. The aim was to investigate the olfactory dysfunctions in association with other post-COVID symptoms.Material And MethodsObservational, descriptive and single-center study. The patients had confirmed mild COVID-19 and subjective olfactory dysfunction of more than a month of evolution, which was assessed by Sniffin' Sticks Olfactory Test.ResultsA total of 86 patients participated. The mean age was 37.2 years (SD 9.82). 70.9% reported parosmia and 46.5% symptoms of brain fog. A pathological test result was obtained in 72.1% of the participants. The most failed pen was 11 (apple) in 76.7%. Anosmia of pen 15 (anise) was reported more frequently in 24.4% and cacosmia of pen 9 (garlic) in 27.9%. We observed a significant association between patients who reported parosmias and brain fog (RR 2.18; p=0.018), also between parosmia and phantosmia (RR 6.042; p<0.001).ConclusionThere is some pathological selectivity for certain test pens, a higher prevalence of cognitive symptoms and many patients with combined parosmia and brain fog.Copyright © 2023 Elsevier España, S.L.U. All rights reserved.

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