• Marion Pépin, Hélène Levassort, Julie Boucquemont, Oriane Lambert, Natalia Alencar de Pinho, Monica Turinici, Catherine Helmer, Marie Metzger, Lynda Cheddani, Luc Frimat, Christian Combe, Denis Fouque, Maurice Laville, Carole Ayav, Sophie Liabeuf, Christian Jacquelinet, Laurent Teillet, Bénédicte Stengel, Ziad A Massy, and CKD-REIN Study Collaborators.
• Geriatrics, APHP, UVSQ, Hopital Ambroise-Pare, Boulogne-Billancourt, France marion.pepin@aphp.fr.
• J. Neurol. Neurosurg. Psychiatr. 2023 Jun 1; 94 (6): 457466457-466.

BackgroundChronic kidney disease (CKD) is associated with cognitive impairment in general population. We assessed the association between kidney and cognitive functions in patients with CKD and the influence of cardiovascular (CV) risk factors, and depression on this association.MethodsThe CKD-Renal Epidemiology and Information Network cohort included 3033 patients with CKD stages 3-4, followed for 5 years. Cognitive function was assessed with the Mini-Mental State Examination (MMSE) and estimated glomerular filtration rate (eGFR) with the CKD-Epidemiology Collaboration equation-creatinin formula. Evolution of the MMSE score over time and its association with baseline eGFR were investigated with linear mixed models. We assessed the risk of incident cognitive outcome (hospitalisation or death with relevant International Classification of Disease-10 codes), with a Cox proportional hazard model.ResultsThe mean age was 66.8, the mean eGFR was 33 mL/min/1.73 m2 and 387 patients (13.0%) had an MMSE score below 24 at baseline. A 10 mL/min/1.73 m2 decrement of baseline eGFR was associated with a mean MMSE decrease of 0.12 (95% CI 0.04 to 0.19) after adjustment for demographic characteristics, depression, CV risk factors and disease; but baseline eGFR was not associated with MMSE temporal evolution. HR for cognitive outcome during follow-up (median 2.01 years) associated with a 10 mL/min/1.73 m2 decrement of baseline eGFR was 1.35 (1.07, 1.70) (p=0.01) after adjustment.ConclusionsIn patients with CKD, lower eGFR was associated with worse cognitive performance and incident cognitive events, independently of demographics, CV risk factors and depression.Trial Registration NumberNCT03381950.© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.

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