• Clin Med (Lond) · Jan 2023

    The oligometastatic paradigm and the role of radiotherapy.

    • Killian Nugent and James Good.
    • Genesiscare UK and Oxford University Hospital, Oxford, UK killian.nugent@ouh.nhs.uk.
    • Clin Med (Lond). 2023 Jan 1; 23 (1): 616461-64.

    AbstractMost cancer-related deaths are due to metastatic disease. There is now an emerging evidence base suggesting that a subgroup of metastatic patients benefit significantly from local resection (surgery) or ablation (stereotactic ablative body radiation, SABR) of their metastatic sites. These patients are in what has been termed the 'oligometastatic state', a transitional window between local and disseminated disease where locally ablative, metastasis-directed therapy prolongs progression-free survival, improves overall survival and sometimes achieves cure. Appropriately selecting those who fit this oligometastatic phenotype, while integrating advances in ablative technologies such as SABR with modern systemic treatments, is an evolving challenge for oncologists.© Royal College of Physicians 2023. All rights reserved.

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