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Editorial Comment
Exosomes as perioperative therapeutics to limit organ injury.
- Andrew Owen, Creed M Stary, and Eric R Gross.
- Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, UK. Electronic address: a.owen.2@bham.ac.uk.
- Br J Anaesth. 2023 Mar 1; 130 (3): 248250248-250.
AbstractPerioperative organ injury is a frequent and major complication for the ∼240 million people undergoing surgery worldwide annually. Ischaemic preconditioning is a powerful technique that reduces organ injury in experimental models of heart, lung, gut, brain, and kidney ischaemia-reperfusion injury. However, ischaemic preconditioning has been a challenge to translate into clinical practice. We describe how utilising isolated pre-conditioned exosomes (secreted vesicles containing many cell-survival mediators), some of the translational hurdles of ischaemic preconditioning can be overcome. Delivery of exosomes in the perioperative period could become a promising new therapeutic strategy to prevent perioperative organ injury.Copyright © 2022 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
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