• Jun Chen, Jian-an Ren, Wei-wei Zhang, Guo-sheng Gu, Chao-gang Fan, Xin-bo Wang, and Jie-shou Li.
• School of Medicine, Nanjing University, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China.
• Zhonghua Wai Ke Za Zhi. 2011 Apr 1;49(4):335-40.

ObjectiveTo evaluate the open and closed management treatment of liver injury in rats with sepsis and abdominal compartment syndrome (ACS).MethodsThe sepsis and ACS rats (n = 72) were randomized divided into two groups. One group used closed management (n = 36), the other accepted the open abdomen management (n = 36). The rats were killed at 1, 6 h, 1, 3, 5, 7 d after operation. Blood was collected for liver function tests. Liver sections assessed pathologically and the expressions of Toll-like receptor 4 (TLR4), tumor necrosis factor (TNF)-α, interleukin (IL)-6, signal transducers actuators of transcription (STAT3) and suppressor of cytokine signaling 3 (SOCS3) of rat livers were examined by RT-PCR.ResultsThe early stage after operation, TNF-α and IL-6 concentrations, STAT3 expressions in rat liver were higher in open abdomen rats than the closed management ones (P < 0.05). TLR4 and SOCS3 expressions were lower in open abdomen rats than the closed management ones (P < 0.05). Aspartate aminotransferase, alanine aminotransferase levels also was lower in open abdomen ones (P < 0.05).ConclusionsThe randomized study demonstrates that open abdomen management could improve liver regeneration in the early stage after operation. Also open abdomen could reduce inflammatory response by reducing TLR4 expressions.

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