• Khalid Mahmood, Nauman Ismat Butt, Fahmina Ashfaq, and Sabeen Aftab.
• Khalid Mahmood, MBBS, FCPS. Assistant Professor, Department of Medicine & Allied, Azra Naheed Medial College, Superior University, Lahore, Pakistan.
• Pak J Med Sci. 2023 Jan 1; 39 (1): 307309307-309.

AbstractA 72-year-old asthmatic gentleman with a history of recurrent sinusitis and chronic bronchitis presented with shortness of breath and progressively worsening hypoxemic respiratory failure. His CT chest demonstrated airspace disease bilaterally with ground-glass opacifications. He had peripheral eosinophilia with raised inflammatory markers but negative work up of infection. On further investigation, ANA was positive, titer 1:160, speckled pattern and both pANCA and cANCA were present. The patient was diagnosed with Eosinophilic Granulomatosis with Polyangiitis (EGPA) and started on intravenous steroids and cyclophosphamide. A rare multi-organ vasculitis, EGPA is hallmarked by asthma, sinusitis and eosinophilia. In initial stages vasculitic involvement is not usually seen thereby making EGPA a diagnostic challenge.Copyright: © Pakistan Journal of Medical Sciences.

4 keywords...

hide…