• Ojaswee Sherchand, Apeksha Niraula, Bijaya Mishra, Manish Subedi, and Robin Maskey.
• Department of Biochemistry, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal.
• JNMA J Nepal Med Assoc. 2022 Jul 1; 60 (251): 600603600-603.

IntroductionAutoimmune thyroid disease is characterised by the generation of autoantibodies against self-antigens such as thyroid peroxidase, thyroglobulin, and thyroid-stimulating hormone receptor. Recent studies have implicated the role of hypovitaminosis D to immune dysfunction, failure of self-tolerance and generation of autoantibodies. This study aimed to find out the prevalence of autoimmune thyroid disease among hypovitaminosis D patients in a tertiary care centre.MethodsA descriptive cross-sectional study was conducted among participants between the ages of 18 years to 65 years who visited the Department of Biochemistry of a tertiary care centre between the periods of July 2018 to December 2019. The study was initiated after receiving ethical approval from the Institutional Review Committee (Reference number: 42,8/074/075-IRC). Data was collected using a self-administered questionnaire followed by anthropometric measurement and blood collection. Thyroid hormone, thyroid peroxidase antibody and 25-hydroxy vitamin D were measured by chemiluminescence technique. Convenience sampling was used. Point estimate and 95% Confidence Interval were calculated.ResultsAmong 83 patients, 39 (46.98%) (42.32-51.63, 95% Confidence Interval) had autoimmune thyroid disease.ConclusionsThe prevalence of autoimmune thyroid disease among patients with hypovitaminosis D was similar to studies conducted in comparable settings.Keywordsautoimmune diseases; prevalence; thyroid; vitamin D.

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