• Satoshi Yoshimura, Takeyuki Kiguchi, Taro Irisawa, Tomoki Yamada, Kazuhisa Yoshiya, Changhwi Park, Tetsuro Nishimura, Takuya Ishibe, Hitoshi Kobata, Masafumi Kishimoto, Sung-Ho Kim, Yusuke Ito, Taku Sogabe, Takaya Morooka, Haruko Sakamoto, Keitaro Suzuki, Atsunori Onoe, Tasuku Matsuyama, Satoshi Matsui, Norihiro Nishioka, Yohei Okada, Yuto Makino, Shunsuke Kimata, Shunsuke Kawai, Ling Zha, Kosuke Kiyohara, Tetsuhisa Kitamura, and Taku Iwami.
• Department of Preventive Services, Kyoto University School of Public Health, Kyoto, Japan.
• Resuscitation. 2023 Mar 1; 184: 109700109700.

AimLife-threatening electrocardiographic (ECG) findings aid in the diagnosis of acute coronary syndrome (ACS), which has not been well-evaluated in patients with out-of-hospital cardiac arrest (OHCA). This study aimed to evaluate the diagnostic test accuracy (DTA) of ST-elevation myocardial infarction (STEMI) equivalents following the return of spontaneous circulation (ROSC) in patients with OHCA to identify patients with ACS.MethodsUsing the database of the Comprehensive Registry of In-Hospital Intensive Care for OHCA Survival study from 2012 to 2017, patients aged ≥18 years with non-traumatic OHCA and ventricular fibrillation or pulseless ventricular tachycardia on the arrival of emergency medical service personnel or arrival at the emergency department, who achieved ROSC, were included. Patients without ST-segment elevation or complete left bundle branch block on ECG and those who did not undergo ECG or coronary angiography, were excluded from the study. We evaluated the DTA of STEMI equivalents for the diagnosis of ACS: isolated T-wave inversion, ST-segment depression, Wellens' signs, and ST-segment elevation in lead aVR.ResultsIsolated T-wave inversion and Wellens' signs had high specificity for ACS with 0.95 (95% confidence interval [CI], 0.87-0.99) and 0.92 (95% CI, 0.82-0.97), respectively, but their positive likelihood ratios were low, with a wide range of 95% CI: 1.89 (95% CI, 0.51-7.02) and 0.81 (95% CI, 0.25-2.68), respectively.ConclusionThe DTA of STEMI equivalents for the diagnosis of ACS was low among patients with OHCA. Further investigation considering the measurement timing of the ECG after ROSC is required.Copyright © 2023 Elsevier B.V. All rights reserved.

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