• Ir J Med Sci · Oct 2023

    Oral combined hormonal contraceptive associated with protection against allodynia in migraine in a cross-sectional study.

    • Aline Vitali-Silva, Isabella G Vuolo, Lara H Gonzalez, Renata F Galvão, Silvia G Farges, Valéria A Bello, and Regina C Poli-Frederico.
    • Medical School, Pontifical Catholic University of Paraná, Londrina-PR, Brazil. alinevitalidasilva@gmail.com.
    • Ir J Med Sci. 2023 Oct 1; 192 (5): 220322082203-2208.

    IntroductionFor the most part, migraine afflicts young women who often need to use the hormonal contraceptive method.ObjectiveTo evaluate the effects of using exogenous estrogen, present in combined hormonal contraceptives (CHC) and progestin-only methods on the prevalence of allodynia in women with migraine.MethodsStudy comprising women diagnosed with migraine, with or without aura, who were not pregnant, breastfeeding, or menopausal. The study was conducted via the digital platform. Data were collected relating to demographics, contraceptive method, anthropometric information, smoking habits, and migraine-related symptoms. The participants then answered the following validated, self-administered questionnaires: Migraine Disability Assessment (MIDAS), Allodynia Symptom Checklist, Generalized Anxiety Disorder (GAD-7), and Beck's Depression Inventory (BDI). In order to determine the variables associated with allodynia, two binary logistic regression models were used.ResultsFour hundred eighty-six women took part in the study. Of these, 205 used CHC, 89 used a progestin-only method, and 192 participants did not use any form of hormonal contraception. Allodynia was identified in 411 (84.6%) participants. Allodynia was linked to the presence of aura (OR = 2.76; CI 95% 1.55-4.91; p = 0.001), menstrually related migraine (OR = 2.14; CI 95% 1.28-3.57; p = 0.004), greater disability (MIDAS score 23 vs. 8; p < 0.001), depression (BDI score 14 vs. 10; p < 0.001), and anxiety (GAD-7 score 11 vs. 8; p < 0.001). In adjusted analysis, CHC was associated to protection against allodynia when jointly evaluated all CHC regimens (OR = 0.49 CI 95% 0.26-0.92; p = 0.028), as well as oral CHC individually (OR = 0.48 CI 95% 0.25-0.92; p = 0.027).ConclusionCHC reduced the chances of women with migraine getting allodynia.© 2023. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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