• Jingjing Liu and WongStanley Sau ChingSSCFrom the Department of Anesthesiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine.Laboratory and Clinical Research Institute for Pain, Department of Anesthesiology, The University of Hong Kong, Hong Kong SAR, P.R..
• From the Department of Anesthesiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine.
• Anesth. Analg. 2023 Jul 1; 137 (1): 137152137-152.

AbstractPain perception provides evolutionary advantages by enhancing the probability of survival, but chronic pain continues to be a significant global health concern in modern society. Various factors are associated with pain alteration. Accumulating evidence has revealed that obesity correlates with enhanced pain perception, especially in chronic pain individuals. Existing dietary patterns related to obesity are primarily high-fat diets (HFD) and calorie restriction (CR) diets, which induce or alleviate obesity separately. HFD has been shown to enhance nociception while CR tends to alleviate pain when measuring pain outcomes. Herein, this review mainly summarizes the current knowledge of the effects of HFD and CR on pain responses and underlying molecular mechanisms of the immunological factors, metabolic regulation, inflammatory processes, Schwann cell (SC) autophagy, gut microbiome, and other pathophysiological signaling pathways involved. This review would help to provide insights on potential nonpharmacological strategies of dietary patterns in relieving pain.Copyright © 2022 International Anesthesia Research Society.

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