• Juliana Dias Gonçalves Dos Santos, SouzaFabíola Isabel Suano deFIS0000-0003-3848-4752Centro Universitário Fundação Santo André, Faculdade de Medicina do ABC, Department of Pediatrics - Santo André (SP), Brazil.Universidade Federal de São Paulo, Department of Pediatrics - São Paulo (SP), Br, João Carlos Pina Faria, Luciana Satiko Sawamura, Anelise Del Vecchio Gessullo, and SarniRoseli Oselka SaccardoROS0000-0001-5839-0871Centro Universitário Fundação Santo André, Faculdade de Medicina do ABC, Department of Pediatrics - Santo André (SP), Brazil.Universidade Federal de São Paulo, Department of Pediatrics - São Paulo (SP), Bra.
• Centro Universitário Fundação Santo André, Faculdade de Medicina do ABC, Department of Pediatrics - Santo André (SP), Brazil.
• Rev Assoc Med Bras (1992). 2023 Jan 1; 69 (2): 285290285-290.

ObjectiveThe aim of this study was to describe homocysteine concentrations in overweight and obese children and adolescents and relate them to blood pressure levels, renal function, and insulin resistance.MethodsThis is a cross-sectional and observational study with 64 overweight children and adolescents (mean age: 11.6±3.5 years) in outpatient follow-up. The following parameters were evaluated: body mass index z-score, waist-to-height circumference ratio, pubertal stage, blood pressure, serum homocysteine, glycemia, insulin, lipid profile, renal function, high-sensitivity C-reactive protein, microalbuminuria, and creatinuria. Statistical analysis: analysis of variance and logistic regression (dependent variable: homocysteine) (p<0.05).ResultsThe mean body mass index z-score was 2.9±1.1. The mean homocysteine concentrations were 8.6±2.2 μmol/L (10th and 90th percentiles: 6.6 and 11.2 μmol/L, respectively), with no difference when compared with children with severe obesity and obesity/overweight (p=0.431). High values of waist-to-height ratio (93.8%), systolic blood pressure (18.8%), diastolic blood pressure (12.5%), glycemia (4.7%), low-density lipoprotein cholesterol (31.1%), triglycerides (35.9%), non-high-density lipoprotein cholesterol (34.4%), and microalbuminuria (21.9%) were obtained. The mean glomerular filtration rate was 122.9±24.6 mL/min/1.73 m². Homocysteine concentrations were not associated with any of the studied variables (R²=0.095).ConclusionHomocysteine concentrations in overweight children and adolescents (mean 8.6±2.2 μmol/L) were not associated with body mass index z-score, blood pressure, renal function, and insulin resistance.

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