• Molly B Kraus, Kahlin Leuzinger, Emily Reynolds, Alice Gallo de Moraes, Julianna Smith, Emily E Sharpe, Jaxon Quillen, Heidi Kosiorek, and Monica W Harbell.
• Anesthesiology, Department of Anesthesiology and Perioperative Medicine, 5777 E Mayo Blvd, Phoenix, AZ 85054, United States of America. Electronic address: kraus.molly@mayo.edu.
• J Crit Care. 2023 Jun 1; 75: 154233154233.

PurposeTo identify cases of diabetes insipidus (DI) related to sedation in the ICU to determine which medications pose the greatest risk and understand patterns of presentation.Materials And MethodsWe searched PubMed, Embase, Scopus, Google Scholar, and Web of Science. Search terms included "polyuria," "diabetes insipidus," "hypnotics and sedatives," "sedation," as well as individual medications. Case reports or series involving DI or polyuria related to sedation in the ICU were identified.ResultsWe identified 21 cases of diabetes insipidus or polyuria in the ICU attributed to a sedative. Dexmedetomidine was implicated in 42.9% of cases, followed by sevoflurane (33.3%) and ketamine (23.8%). Sevoflurane was implicated in all 7 cases in which it was used (100%; 95% CI 59.0%, 100.0%), dexmedetomidine in 9 of 11 cases (81.8%; 95% CI 48.2, 97.7), and ketamine in 5 of 9 cases (55.6%; 95% CI 21.2%, 86.3%).ConclusionsAwareness of the potential for sedatives to cause DI may lead to greater identification with swifter medication discontinuation and subsequent resolution of DI.Copyright © 2022 Elsevier Inc. All rights reserved.

18 keywords...

hide…