• Yesim Bayoglu Tekin, Berna Dilbaz, Sadiman Kiykac Altinbas, and Serdar Dilbaz.
• Department of Obstetric and Gynecology, Agri Patnos Public Hospital, Ministry of Health, Patnos-Agri, Turkey.
• Fertil. Steril. 2011 Feb 1;95(2):492-6.

ObjectiveTo compare efficacy of the levonorgestrel-releasing intrauterine system (LNG-IUS; Mirena) with depot GnRH analogue (GnRH-a; gosareline acetate; Zoladex) on endometriosis-related chronic pelvic pain (CPP) in patients with severe endometriosis during 12 months.DesignProspective, randomized, controlled study.SettingThe reproductive endocrinology unit of a tertiary, research and education hospital.Patient(S)Forty women with severe endometriosis (revised The American Fertility Society [AFS] classification >40) and endometriosis-related CPP and control groups were enrolled in the study.Intervention(S)The patients were treated with either LNG-IUS (n = 20) or GnRH-a (n = 20). The GnRH-a dose was repeated every 4 weeks for 24 weeks.Main Outcome Measure(S)Scores of CPP were evaluated using a visual analogue scale (VAS) and total endometriosis severity profile (TESP).Result(S)The TESP score decreased in the LNG-IUS group at first, third, and sixth month follow-up visits, whereas at the 12th month follow-up visit, the TESP scores were increased to values similar to pretreatment values. Although the VAS score had no significant alteration during the follow-up period in the LNG-IUS group, the GnRH-a group showed a significant decrease in the VAS score and TESP score at the end of 1 year. The LNG-IUS treatment showed a lower patient satisfaction.Conclusion(S)Both treatment modalities showed comparable effectiveness in the treatment of CPP-related endometriosis.Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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