• S Selcuk Atamanalp, M Sait Keles, R Selim Atamanalp, Hamit Acemoglu, and Esra Laloglu.
• S. Selcuk Atamanalp, Professor, Department of General Surgery, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
• Pak J Med Sci. 2013 Jan 1; 29 (1): 187190187-90.

ObjectiveGallbladder stones are common in the Western world, and 70% to 80% of gallstones are cholesterol stones. This study investigates the effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration.MethodologyThe gallstones of 75 patients with cholelithiasis were examined using spectrophotometry.ResultsHigh serum cholesterol and LDL levels were associated with high cholesterol stone rates (86.7% vs. 40.0%, P < 0.001; 75.0% vs. 48.9%, P < 0.05, respectively). Similarly, high serum cholesterol and LDL levels were correlated with high gallbladder stone cholesterol concentrations (63.6% vs. 44.4%, P < 0.001; 62.3% vs. 46.0%, P < 0.001, respectively). In contrast, low serum HDL levels do not seem to affect the occurrence of gallbladder cholesterol stones (60.0% vs. 58.3%, respectively, P > 0.05) or gallbladder stone cholesterol concentrations (50.8% vs. 52.4%, respectively, P > 0.05).ConclusionThe relationship between cholesterol, LDL, and HDL levels and cholesterol gallstone formation is multifactorial and complex and is also dependent on other individual properties.

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