• Shock · Feb 2023

    Review

    Emerging Role of Extracellular RNA in Innate Immunity, Sepsis, and Trauma.

    • Brittney Williams, Rosemary Kozar, and Wei Chao.
    • Translational Research Program, Department of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, Maryland.
    • Shock. 2023 Feb 1; 59 (2): 190199190-199.

    AbstractSepsis and trauma remain the leading causes of morbidity and mortality. Our understanding of the molecular pathogenesis in the development of multiple organ dysfunction in sepsis and trauma has evolved as more focus is on secondary injury from innate immunity, inflammation, and the potential role of endogenous danger molecules. Studies of the past several decades have generated evidence for extracellular RNAs (exRNAs) as biologically active mediators in health and disease. Here, we review studies on plasma exRNA profiling in mice and humans with sepsis and trauma, the role and mode of action by exRNAs, such as ex-micro(mi)RNAs, in host innate immune response, and their potential implications in various organ injury during sepsis and trauma.Copyright © 2022 by the Shock Society.

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