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- Seiji Kobayashi, Kazunori Fugo, Ryo Hatano, Kazuto Yamazaki, Chikao Morimoto, and Hiroyuki Terawaki.
- Division of Nephrology, Department of Internal Medicine, Teikyo University Chiba Medical Center, Japan.
- Intern. Med. 2023 Apr 1; 62 (7): 104310481043-1048.
AbstractAs coronavirus disease 2019 (COVID-19) vaccine booster campaigns progress worldwide, new reports of complications following COVID-19 vaccination have emerged. We herein report a case of new-onset anti-glomerular basement membrane (GBM) disease concomitant with myeloperoxidase-antineutrophil cytoplasmic antibody positivity concurrent with high levels of interleukin (IL)-26 following the second dose of the Pfizer-BioNTech COVID-19 vaccine. The temporal association with vaccination in this case suggests that an enhanced neutrophilic immune response through IL-26 may have triggered necrotizing glomerulonephritis and a T-cell-mediated immune response to GBMs, leading to the development of anti-GBM antibodies, with an enhanced B-cell response after the vaccination triggering anti-GBM IgG and the onset of anti-GBM disease.
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