• Internal medicine · Sep 2023

    Case Reports

    Coexistence of Pheochromocytoma and Primary Aldosteronism due to Multiple Aldosterone-producing Micronodules in the Ipsilateral Adrenal Gland.

    • Satoshi Ugi, Maya Yonishi, Daisuke Sato, Nobuhiko Nakaizumi, Osamu Horikawa, Yukihiro Fujita, Kentaro Inoue, Akinori Wada, Susumu Kageyama, Akihiro Kawauchi, Michiko Hino, Mai Noujima, Yuto Yamazaki, Hironobu Sasano, and Hiroshi Maegawa.
    • Department of Medicine, Shiga University of Medical Science, Japan.
    • Intern. Med. 2023 Sep 15; 62 (18): 268526912685-2691.

    AbstractA 46-year-old woman was referred for hypertension and a right adrenal tumor. Primary aldosteronism (PA) was suspected because of the high plasma aldosterone concentration-to-plasma renin activity ratio. However, a subsequent evaluation revealed coexistent PA and pheochromocytoma. We performed laparoscopic right adrenalectomy. Histology of the resected adrenal gland confirmed pheochromocytoma and multiple aldosterone-producing adrenocortical micronodules. Following adrenalectomy, the urinary catecholamine levels normalized, and hyperaldosteronism improved but persisted. Hypertension also improved but persisted and was normalized with spironolactone. The clinical course indicated that the PA lesions were likely bilateral. This was a histologically proven case of coexistent pheochromocytoma and PA due to multiple aldosterone-producing micronodules.

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