• Internal medicine · Sep 2023

    Case Reports

    Aplastic Anemia with Epstein-Barr Virus Reactivation after Anti-thymocyte Globulin Therapy.

    • Yo Kawarada, Ryujiro Hara, Toshihiko Kitahara, Hiroki Numata, Shigeki Watanabe, Masatoshi Yamada, and Kiyoshi Ando.
    • Department of Hematology, Ebina General Hospital, Japan.
    • Intern. Med. 2023 Sep 1; 62 (17): 255325572553-2557.

    AbstractLymphoproliferative disorders and Epstein-Barr virus reactivation (EBV-LPDs) have various forms of onset, ranging from infectious mononucleosis-like syndrome (IM-like) to lymphoma, although whether or not IM-like progresses to lymphoma remains unclear. A 61-year-old man was diagnosed with aplastic anemia (AA). Polyclonal atypical B-lymphocytes were observed in the peripheral blood, and IM-like was diagnosed. Atypical lymphocytes disappeared, but a gastrointestinal examination revealed diffuse large B-cell lymphoma (DLBCL). Rituximab was initiated but later discontinued because of severe acute respiratory syndrome coronavirus 2 infection. Pancytopenia due to AA exacerbation recurred. The patient ultimately died of multiple organ failure due to bacterial infection.

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