• Grasiele Sausen, Tarsila Vieceli, Clarissa Garcia Rodrigues, Daniel Kipper, Airton Tetelbom Stein, and Guilherme Brasil Grezzana.
• PhD. Coordinator of the Experimental Research Section, Instituto de Cardiologia do Rio Grande do Sul, Fundação Universitária de Cardiologia (IC-FUC), Porto Alegre (RS), Brazil.
• Sao Paulo Med J. 2018 Jan 1; 136 (6): 501504501-504.

BackgroundCentral blood pressure is a factor that may predict cardiovascular events. However, its use in clinical practice is not well consolidated. Therefore, the aim of our study will be to summarize the use of central hemodynamic parameters to predict cardiovascular-related outcomes and all-cause mortality.Design And SettingProtocol for systematic review of longitudinal observational studies conducted in healthcare institutions, as presented in the studies included.MethodsWe will perform a systematic search in the electronic databases MEDLINE (via PubMed), EMBASE and LILACS (via Virtual Health Library (VHL)), using health descriptors terms for elderly people and for hemodynamic indices of central blood pressure. We will include articles that evaluated hemodynamic indices and at least one of the following outcomes: all-cause mortality, total cardiovascular death, total non-cardiovascular death, myocardial infarction, stroke, coronary artery restenosis after percutaneous coronary intervention, revascularization and aortic syndromes. Two independent reviewers will conduct analysis on the abstracts selected and on the full-text articles. Two reviewers will independently perform data extraction and evaluate the methodological quality of the articles selected, and a third reviewer will evaluate any divergences. The methodological quality of the studies will be assessed in accordance with the ROBINS-I tool (Risk Of Bias In Non-randomized Studies of Interventions).Results And ConclusionsThrough this systematic review, we intend to summarize evidence that supports the use of central hemodynamic parameters for central blood pressure to diagnose and perform prognostics on arterial hypertension in elderly patients within clinical practice and predict future cardiovascular events in this population.RegistrationProspero - CRD42018085264.

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