Coronavirus disease 2019 (COVID-19) pneumonia is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is frequently accompanied by various sequelae. Interstitial lung diseases (ILDs) are observed in COVID-19 pneumonia patients after recovery, probably due to persistent inflammation in the lungs. ⋯ The patient was diagnosed with ILD three months after COVID-19 pneumonia. Although the exact mechanism is unknown, the autoantibody-induced immune response might have been the pulmonary fibrosis trigger in this patient.
Tomoya Tateishi, Sho Shimada, Takashi Yamana, Yuki Iijima, Rie Sakakibara, Takahiro Mitsumura, Sho Shibata, Takayuki Honda, Tsuyoshi Shirai, Tsukasa Okamoto, Meiyo Tamaoka, Tsuneo Sasai, and Yasunari Miyaz... more aki. less
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
Intern. Med. 2023 May 1; 62 (9): 132313281323-1328.
AbstractCoronavirus disease 2019 (COVID-19) pneumonia is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is frequently accompanied by various sequelae. Interstitial lung diseases (ILDs) are observed in COVID-19 pneumonia patients after recovery, probably due to persistent inflammation in the lungs. We herein report a case of ILD with anti-signal recognition particle antibodies following severe COVID-19 pneumonia. The patient was diagnosed with ILD three months after COVID-19 pneumonia. Although the exact mechanism is unknown, the autoantibody-induced immune response might have been the pulmonary fibrosis trigger in this patient.