• Internal medicine · Sep 2023

    Case Reports

    Two Cases of Rapidly Progressive Fatty Liver Disease due to Pancreatic Exocrine Insufficiency without a History of Surgery.

    • Kazuhide Takata, Takahiro Nagata, Keisuke Matsumoto, Takashi Miyayama, Kumiko Shibata, Hiromi Fukuda, Ryo Yamauchi, Atsushi Fukunaga, Takashi Tanaka, Keiji Yokoyama, Satoshi Shakado, Shotaro Sakisaka, and Fumihito Hirai.
    • Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
    • Intern. Med. 2023 Sep 15; 62 (18): 266726732667-2673.

    AbstractWe herein report two cases of rapidly progressive fatty liver (FL) disease due to pancreatic exocrine insufficiency (PEI) without a surgical history. Two women, 59 and 72 years old, with no history of abdominal surgery presented to our hospital with severe anorexia and nausea persisting for one week. Examinations revealed progressive, marked FL disease with hepatomegaly and PEI, for which pancreatic enzyme replacement therapy was effective. Commonly known causes of PEI include chronic pancreatitis, abdominal surgery (e.g. pancreaticoduodenectomy), pancreatic cancer, and obstruction of the pancreatic duct, none of which were present in either of these two cases.

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