• Internal medicine · Sep 2023

    Possible Use of Non-purine Selective Xanthine Oxidoreductase Inhibitors for Prevention of Exercise-induced Acute Kidney Injury Associated with Renal Hypouricemia: A Case Report.

    • Chiharu Aizawa, Masahiro Okabe, Daisuke Takahashi, Makoto Sagasaki, Mao Watanabe, Toshinari Fujimoto, Yuuki Yoshioka, Ai Katsuma, Ai Kimura, Daisuke Miyamoto, Nana Sato, Ken Okamoto, Kimiyoshi Ichida, Yoichi Miyazaki, and Takashi Yokoo.
    • Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
    • Intern. Med. 2023 Sep 15; 62 (18): 272527302725-2730.

    AbstractExercise-induced acute kidney injury (EIAKI) is frequently complicated with renal hypouricemia (RHUC). In patients with RHUC, limiting anaerobic exercise can prevent EIAKI. However, it is challenging to reduce exercise intensity in athletes. We herein report a 16-year-old Japanese football player with familial RHUC with compound heterozygous mutations in urate transporter 1 (URAT1) who presented with recurrent EIAKI. As prophylaxis (hydration during exercise) could not prevent EIAKI, febuxostat was initiated. EIAKI was not observed for 16 months despite exercising intensively. Hence, non-purine-selective xanthine oxidoreductase inhibitors may decrease the incidence of EIAKI in athletes with RHUC.

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