• Sao Paulo Med J · Jan 2018

    Review

    Carotid intima-media thickness in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): a narrative review.

    • Eduardo Henrique Sena Santos, Pedro José Dos Santos Neto, and SantosItamar de SouzaIS0000-0003-3212-8466MD, PhD. Researcher, Center for Clinical and Epidemiological Research, Hospital Universitário (HU), Universidade de São Paulo (USP), and Associate Professor, Department of Internal Medicine, Faculdade de Medicina .
    • MD. Physician, Imaging Service, and Researcher, Center for Clinical and Epidemiological Research, Hospital Universitário (HU), Universidade de São Paulo (USP), São Paulo (SP), Brazil.
    • Sao Paulo Med J. 2018 Jan 1; 136 (1): 647264-72.

    BackgroundCarotid intima-media thickness (CIMT), as measured by ultrasound, has been used in large studies as a non-invasive marker for subclinical atherosclerosis. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a cohort of 15,105 civil servants in six Brazilian cities that included CIMT evaluation in its baseline assessment. The aim of the present narrative review was to provide an overview of ELSA-Brasil CIMT articles published up to July 31, 2017.Design And SettingNarrative review of ELSA-Brasil CIMT studies using baseline assessment data.MethodsWe searched PubMed for the terms "ELSA-Brasil" and "intima-media". This search yielded 21 published articles using CIMT data from the ELSA-Brasil baseline assessment, which were included in this review. We also present information about intima-media thickness assessment from ongoing onsite reevaluations of the study participants.ResultsMost published studies focused on the association with traditional and novel cardiovascular risk factors. Studies also presented information about the ELSA-Brasil CIMT protocol at baseline and CIMT value distribution in this large sample.ConclusionsAnalyses on the ELSA-Brasil data led to important insights on CIMT interpretation and physiology. Besides the highlighted contributions which have already been made in this field, new data gathered during the ongoing third onsite assessment will enable investigation of substantially new research questions.

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