• Jorgina Lucas-Noll, Mar Lleixà-Fortuño, Lluïsa Queralt-Tomas, Anna Panisello-Tafalla, Misericòrdia Carles-Lavila, and José L Clua-Espuny.
• Regió Sanitària Terres de l'Ebre, Servei Català de la Salut, Tortosa, Tarragona, España. Electronic address: jlucasn@catsalut.cat.
• Aten Primaria. 2023 Mar 1; 55 (3): 102578102578.

ObjectiveTo review the bibliography on stroke costs (ICD-10 code I63) in the field of primary care.DesignSystematic review.Data SourcesPubMed/Medline, ClinicalTrials.gov, Cochrane Reviews, EconLit, and Ovid/Embase between 01/01/2012-12/31/2021 with descriptors included in Medical Subject Heading (MeSH).Selection Of StudiesThose with a description of the costs of activities carried out in the out-of-hospital setting. Systematic reviews were included; prospective and retrospective observational studies; analysis of databases and total or partial costs of stroke as a disease (COI). Articles were added using the snowball method. The studies were excluded because: a) not specifically related to stroke; b) in editorial or commentary format; c) irrelevant after review of the title and abstract; and d) gray literature and non-academic studies were excluded.Data ExtractionThey were assigned a level of evidence according to the GRADE levels. Direct and indirect cost data were collected.Results And ConclusionsThirty studies, of which 14 (46.6%) were related to post-stroke costs and 12 (40%) to cardiovascular prevention costs. The results show that most of them are retrospective analyzes of different databases of short-term hospital care, and do not allow a detailed analysis of the costs by different segments of services. The possibilities for improvement are centered on primary and secondary prevention, selection and pre-hospital transfer, early discharge with support, and social and health care.Copyright © 2023 The Author(s). Publicado por Elsevier España, S.L.U. All rights reserved.

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