• Journal of anesthesia · Apr 2023

    Review Meta Analysis

    Pharmacological prevention of postoperative delirium in patients undergoing cardiac surgery: a bayesian network meta-analysis.

    • Massimo Meco, Enrico Giustiniano, Maurizio Cecconi, and Giovanni Albano.
    • Department of Anesthesia and Intensive Care, San Carlo Clinic, Via Dell'Ospedale, 2, 20030, Paderno Dugnano, Milan, Italy. mmeco63@gmail.com.
    • J Anesth. 2023 Apr 1; 37 (2): 294310294-310.

    AbstractThe incidence of postoperative delirium in patients undergoing cardiac surgery is very high and increases morbidity and mortality. The possibility of pharmacological means to reduce its incidence is very attractive. At present, there is still no clear demonstration that any drug can prevent postoperative delirium in these patients. The aim of this Bayesian network meta-analysis (NMA) was to evaluate whether there is evidence that a drug is effective in reducing the incidence of POD in cardiac surgical patients. Our NMA showed that preoperative ketamine at subanesthetic doses can significantly reduce the incidence of POD. Risperidone also decreases the incidence of POD, but not significantly.© 2023. The Author(s) under exclusive licence to Japanese Society of Anesthesiologists.

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