• Wei Zhang, Mengyu Liao, and Hua Yan.
• Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin Key Laboratory of Ocular Trauma, Laboratory of Molecular Ophthalmology, Tianjin Medical University, Tianjin, China.
• Medicine (Baltimore). 2023 Feb 17; 102 (7): e32893e32893.

RationaleHypersensitivity reactions to intravitreal injection of triamcinolone acetonide (TA) were very rare and had been infrequently reported. In this study, we reported the clinical features of hypersensitivity reactions of TA, explored its management, and analyze the relative factors.Patient Concerns, Diagnosis, Interventions, And OutcomesWe described a case of an immediate hypersensitivity reaction to intravitreal injection of TA following the treatment by pars plana vitrectomy. A 27-year-old man was reported with an immediate hypersensitivity reaction following an intravitreal injection of TA. 0.1 mL TA (40 mg/mL) was injected into the vitreous cavity and then white punctate edema appeared on the surface of the retina. Three days later, the visual acuity was 20/500 and white punctate edema disappeared on the surface of the retina without specific treatment.Conclusions And ImportanceHypersensitivity reaction must be considered in cases of intravitreal injection of TA that may resolve without specific treatment. The clinical intravitreal injection of TA requires filtration to remove excipients.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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