• Internal medicine · Oct 2023

    Case Reports

    Proton Beam Therapy as a Curative Treatment for a Young Case of Unresectable Tracheal Adenoid Cystic Carcinoma.

    • Takashi Kinoshita, Hidenobu Ishii, Yuki Sakazaki, Koichi Azuma, Jun Sasaki, Takaaki Tokito, Masaki Tominaga, Etsuyo Ogou, Tomotaka Kawayama, and Tomoaki Hoshino.
    • Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Japan.
    • Intern. Med. 2023 Oct 1; 62 (19): 287728812877-2881.

    AbstractPrimary tracheal adenoid cystic carcinoma (TACC) is a rare malignancy without an established treatment. Central airway obstruction due to TACC often decreases the quality of life and has life-threatening consequences. A 19-year-old man with unresectable TACC and central airway obstruction suffered from progressive cough and dyspnea after exercise. Proton beam therapy (PBT) was selected as the preferred treatment over systemic anti-cancer chemotherapy for TACC. PBT led to complete remission of TACC and the almost complete disappearance of the respiratory symptoms without adverse events. PBT is a useful and safe treatment for unresectable primary TACC.

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