• Anaesthesia · May 2023

    Randomized Controlled Trial

    A randomised controlled trial of dexmedetomidine for delirium in adults undergoing heart valve surgery.

    • H-B Wang, Y Jia, C-B Zhang, L Zhang, Y-N Li, J Ding, X Wu, Z Zhang, J-H Wang, Y Wang, F-X Yan, S Yuan, and D I Sessler.
    • Department of Anaesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    • Anaesthesia. 2023 May 1; 78 (5): 571576571-576.

    AbstractDexmedetomidine might reduce delirium after cardiac surgery. We allocated 326 participants to an infusion of dexmedetomidine at a rate of 0.6 μg kg-1 for 10 min and then at 0.4 μg.kg-1 .h-1 until the end of surgery; 326 control participants received comparable volumes of saline. We detected delirium in 98/652 (15%) participants during the first seven postoperative days: 47/326 after dexmedetomidine vs. 51/326 after placebo, p = 0.62, adjusted relative risk (95%CI) 0.86 (0.56-1.33), p = 0.51. Postoperative renal impairment (Kidney Disease Improving Global Outcomes stages 1, 2 and 3) was detected in 46, 9 and 2 participants after dexmedetomidine and 25, 7 and 4 control participants, p = 0.040. Intra-operative dexmedetomidine infusion did not reduce the incidence of delirium after cardiac valve surgery but might impair renal function.© 2023 Association of Anaesthetists.

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