• William N Sveen, AntommariaArmand H MathenyAHMDivision of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.Department of Pediatrics, University of Cincinnati, Cincinnati, OH., Stephen J Gilene, and Erika L Stalets.
• Division of Critical Care, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
• Pediatr Crit Care Me. 2023 May 1; 24 (5): 399405399-405.

ObjectivesTo report the prevalence of adverse events in children undergoing apnea testing as part of the determination of death by neurologic criteria (DNC).DesignSingle-center, retrospective study.SettingAcademic children's hospital that is a Level I Trauma Center.PatientsAll children who underwent apnea testing to determine DNC from July 2013 to June 2020.InterventionsNone.Measurements And Main ResultsWe abstracted the medical history, blood gases, ventilator settings, blood pressures, vasoactive infusions, intracranial pressures, chest radiographs, and echocardiograms for all apnea tests as well as any ancillary test. Adverse events were defined as hypotension, hypoxia, pneumothorax, arrhythmia, intracranial hypertension, and cardiac arrest. Fifty-eight patients had 105 apnea tests. Adverse events occurred in 21 of 105 apnea tests (20%), the most common being hypotension (15/105 [14%]) and hypoxia (4/105 [4%]). Five of 21 apnea tests (24%) with adverse events were terminated prematurely (three for hypoxia, one for hypotension, and one for both hypoxia and hypotension) but the patients did not require persistent escalation in care. In the other 16 of 21 apnea tests (76%) with adverse events, clinical changes were transient and managed by titrating vasoactive infusions or completing the apnea test.ConclusionsIn our center, 20% of all apnea tests were associated with adverse events. Only 5% of all apnea tests required premature termination and the remaining 15% were completed and the adverse events resolved with medical care.Copyright © 2023 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

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