• James Neuberger, Susan R Brailsford, Gary Mallinson, Michael F Murphy, and Peter Simmonds.
• Queen Elizabeth Hospital, Birmingham jamesneuberger@hotmail.co.uk.
• Clin Med (Lond). 2023 Mar 1; 23 (2): 151156151-156.

AbstractThe supply of blood, blood products and components in the UK, as elsewhere, is safe, although there is no cause for complacency. Use of blood, blood products and components is not without risk of morbidity and mortality. Transfusion-transmitted infections (TTIs) continue to occur and may severely affect the health and welfare of recipients. As indicated by recent and current inquiries, public interest in these TTIs is huge. The risk of TTI can be mitigated but not abolished. Measures to reduce risk include screening of donors, testing of donations and, where appropriate, treatment of donations. The introduction of newer screening tests might identify some infectious donations but come at a cost, which could exceed a justifiable limit. Thus, the recognition, detection, reporting and investigation of cases of possible TTIs need to be improved. Recipients of blood should understand that, although transfusion in the UK is safe, it is not free of risk and so should be provided with full information so that properly informed consent can be given.© Royal College of Physicians 2023. All rights reserved.

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