• Ryohei Jinbo, Ryuichi Kasahara, Shinichiro Morishita, Junko Kubota, Aya Takano, Shoko Takahashi, Sayaka Kisara, Kazumi Jinbo, Yuichi Yamamoto, Tatsuyuki Kai, Yutaka Shiga, Hideo Kimura, Miki Furukawa, and Takaaki Fujita.
• Department of Rehabilitation, Kita-Fukushima Medical Center, Fukushima, Japan.
• Medicine (Baltimore). 2023 Feb 10; 102 (6): e32901e32901.

AbstractThis study investigates the efficacy of and gender differences in exercise therapy in patients with malignant lymphoma undergoing chemotherapy. Twenty-six patients (13 men, 13 women) received physical therapy (based on the Borg Scale 13) during hospitalization. Physical function was measured using grip and knee extension strength, 6-minute walking distance, and body composition; nutritional status assessed via Mini Nutritional Assessment (MNA®); and serum albumin levels analyzed. Fatigue was evaluated using the Brief Fatigue Inventory, and health-related quality of life was assessed with the Medical Outcome Study 36-Item Short-Form Health Survey (SF-36v2). The analysis of all patients indicated that the right grip strength, skeletal muscle mass, skeletal muscle index, and leg muscle mass significantly decreased, whereas the serum albumin level, MNA® score, and scores of many items of the SF-36v2 significantly increased after chemotherapy. In a gender-specific analysis, only men showed significant declines in the skeletal muscle mass and skeletal muscle index, and improvement in the MNA® score after chemotherapy. In the SF-36v2, there were significant improvements in general health and physical component summary scores among men, and general health and mental component summary scores among women. Exercise therapy at a Borg Scale intensity of 13 may not prevent muscle mass decline in patients with malignant lymphoma, especially male patients. In addition, this study revealed that there is a gender difference in the effect of exercise therapy on quality of life. Thus, gender should be considered in exercise therapy for patients with malignant lymphoma.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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