• Burns · Sep 2023

    Predictive value of lactate dehydrogenase combined with the abbreviated burn severity index for acute kidney injury and mortality in severe burn patients.

    • Ming Jiang, Hongyan Qian, Qiqi Li, Yingying Han, and Kesu Hu.
    • Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province 226001, People's Republic of China; Nantong University Medical School, Nantong, Jiangsu Province 226001, People's Republic of China. Electronic address: marvelousming@163.com.
    • Burns. 2023 Sep 1; 49 (6): 134413551344-1355.

    BackgroundExtensive burns are devastating trauma. This study aimed to explore the predictive value of early lactate dehydrogenase (LDH) level, the abbreviated burn severity index (ABSI) and their combination on acute kidney injury (AKI) and mortality after severe burns.Methods And Results194 severe burn patients (TBSA ≥ 30%) were included. After multivariate analyses, early LDH value (first 24 h after admission) was an independent risk factor for early AKI (OR=1.095, CI,1.025-1.169,p = 0.007) and AKI (OR=1.452, CI,1.131-1.864, p = 0.003) in severe burn patients and was still a significant risk factor for mortality (OR=1.059, CI,1.006-1.115，p = 0.03). In ROC analysis, after combining LDH and ABSI, the AUC values were 0.925 for AKI, 0.926 for stage 3 AKI, and 0.904 for mortality. Based on cut-off values, patients were divided into different risk groups. The cumulative incidence of AKI (within 5 days, 30 days) and survival rate (within 60 days) were analyzed by the Kaplan-Meier method. The mortality, AKI incidence, and AKI staging showed a significant upward trend with the increasing risk level (P < 0.001).ConclusionEarly LDH level is an independent risk factor for early AKI and AKI. LDH combined with ABSI can better predict mortality and AKI than single indicators.Copyright © 2023 Elsevier Ltd and ISBI. All rights reserved.

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