• Hai-Chao Tong, Ying-Chun Li, Le-Yao Li, Hong-Tao Xu, Shuang Ma, Wan-Lin Zhang, Tyler Wildes, Lian-He Yang, and Endi Wang.
• Department of Pathology, the First Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.
• Medicine (Baltimore). 2023 Feb 22; 102 (8): e32965e32965.

RationaleEndometrioid adenofibroma is a benign epithelial neoplasm of the ovary, most of which are often unilateral. The symptoms of endometrioid adenofibroma are often nonspecific and misleading. Therefore, a full understanding of the characteristics, diagnosis, and treatment methods of this disease is of great importance. In this study, we report a 34-year-old woman who was found with an unidentified mass on the right ovary during the physical examination 3 years ago with nosymptoms or signs.Patient ConcernsA 34-year-old Chinese female was found with an unidentified 6 cm mass on the right ovary for 3 years that presented with no symptoms or signs.DiagnosisPelvic ultrasound revealed a 6 cm cystic solid mixed mass on the right ovary. Through histological and immunohistochemical examinations, the tumor mass was finally diagnosed as endometrioid adenofibroma of ovary.InterventionsTo confirm the diagnosis, the ovarian tumor was laparoscopically resected.OutcomesThe patient returned to hospital after 3 months with no recurrence or postoperative complications.LessonsEndometrioid adenofibroma is a benign epithelial neoplasm of the ovary. Complete surgical resection is required and rare cases can recur. Postsurgical pathologic and immunohistochemical testing can confirm a diagnosis of endometrioid adenofibroma. It is important to understand of the key points of differential diagnosis of the disease due to the different prognosis and clinical treatment.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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