• Qiulei Zhang, Chengwei Zhang, and Yongjie Yin.
• Department of Emergency and Critical Care, The Second Hospital of Jilin University, Changchun, China.
• Medicine (Baltimore). 2023 Feb 22; 102 (8): e33081e33081.

RationaleLaryngeal obstruction is a life-threatening adverse event that requires urgent and appropriate management, particularly in patients with coexisting cardiopulmonary and brain comorbidities. However, laryngeal obstruction caused by laryngeal neuroendocrine tumors has rarely been reported.Patient ConcernsNeuroendocrine tumors can cause pathological changes in the neuro-humoral system, and asphyxia caused by airway obstruction has a more adverse effect on patients with neuroendocrine tumors.DiagnosesWe report the case of a 64-year-old man with clinical manifestations of dyspnea. Preoperative and intraoperative pathological examination indicated that the patient was diagnosed with life-threatening airway obstruction caused by a laryngeal neuroendocrine tumor, pneumonia, and scoliosis.InterventionsThe patient underwent laryngeal tumor resection under general anesthesia. He was recovered well and was generally good without the necessity of undergoing radiotherapy and chemotherapy at the 6-months follow-up.OutcomesThis case report has provided an emergency treatment strategy associated with awake intubation. We concluded that flexible establishment of an artificial airway, skilled anesthesia and surgical manipulation, and necessary postoperative intensive care are extremely important for improving the prognosis of patients with severely difficult airway. It is noteworthy that the timely adjust for endotracheal intubation strategy according to the patient's response is needed. It is important for the long-term prognosis of patients to avoid the establishment of a traumatic artificial airway and the occurrence of adverse complications.Lessons1. Introduction; 2. Case presentation; 3. Discussion; 4. Conclusion.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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