• Xuelian Tian, Juan Guo, Jinying Liao, Meng He, Yinwen Shi, and Li Tang.
• Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
• Medicine (Baltimore). 2023 Feb 22; 102 (8): e32950e32950.

RationaleAngle-closure glaucoma secondary to iridocorneal endothelial syndrome (ICE) is challenging to treat, especially in patients who have already undergone multiple surgical procedures. Long-term success is difficult to achieve with traditional filtration surgery again. This case report describes a novel nonbleb-dependent surgery for managing such a young patient.Patient ConcernsA 30-year-old male with glaucoma secondary to ICE was referred to West China Hospital, Sichuan University for uncontrolled intraocular pressure following multiple failed filtering surgeries under maximum topical antiglaucoma medications in his right eye.DiagnosesThe patient was diagnosed with angle-closure glaucoma secondary to ICE in the right eye based on a series of ophthalmic examinations.InterventionsPenetrating canaloplasty was performed to manage glaucoma secondary to ICE in the right eye.OutcomesThe patient's visual acuity improved, the intraocular pressure was reduced to 11 to 15 mm Hg through 30 months of follow-up, and no antiglaucoma medication or additional surgical procedures were needed.LessonsPenetrating canaloplasty could be considered as an option for the treatment of refractory angle-closure glaucoma secondary to ICE with extensive angle adhesion.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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