• Lucile L Adams-Campbell, Jennifer Hicks, Kepher Makambi, Pamela Randolph-Jackson, Mary Mills, Claudine Isaacs, and Chiranjeev Dash.
• Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C, United States. Electronic address: lla9@georgetown.edu.
• J Natl Med Assoc. 2023 Apr 1; 115 (2): 199206199-206.

BackgroundCancer treatment related fatigue (CTRF) is one of the most debilitating side effects of adjuvant radiation therapy (RT). Several studies have found that physical activity (PA) may be an effective intervention to decrease fatigue and enhance QOL in cancer survivors. The primary objective of the PEDLAR study is to test the feasibility of an easily administered 8-week structured moderate-intensity PA intervention, delivered concurrently with RT, in reducing CTRF and improving health-related QOL among African-American breast cancer patients. This study is also designed to provide pilot data on the acceptability and adherence of PA interventions in African-American women with breast cancer.MethodsIt is a prospective, 2-arm, 8-week feasibility trial. Participants are randomized to either a structured, moderate-intensity aerobic training exercise regimen concurrent with radiotherapy or a control group.ResultsParticipants in intervention group reported high satisfaction with exercise and adherence was >75% for exercise sessions.ConclusionsAfrican-American breast cancer patients in a moderate-intensity 75 min/wk aerobic exercise intervention had marginally lower fatigue at 8-wk follow-up compared to baseline. The control group participants had marginally higher fatigue at 8-wk follow-up compared to baseline. Participants in the intervention group reported slightly better quality of life at 8-wk follow-up compared to baseline (P = 0.06).Copyright © 2023 National Medical Association. Published by Elsevier Inc. All rights reserved.

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