• J Clin Monit Comput · Oct 2023

    Clinical Trial

    Associations between clinical interventions and transcutaneous blood gas values in postoperative patients.

    • Sandra A Thy, Andreas O Johansen, André Thy, Henrik H Sørensen, Jesper Mølgaard, Nicolai B Foss, Palle Toft, Christian S Meyhoff, and Eske K Aasvang.
    • Department of Anesthesiology, Center for Cancer and Organ Dysfunction, Copenhagen University Hospital-Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. sandraajeppesen@hotmail.com.
    • J Clin Monit Comput. 2023 Oct 1; 37 (5): 125512641255-1264.

    PurposePostoperative monitoring of circulation and respiration is pivotal to guide intervention strategies and ensure patient outcomes. Transcutaneous blood gas monitoring (TCM) may allow for noninvasive assessment of changes in cardiopulmonary function after surgery, including a more direct assessment of local micro-perfusion and metabolism. To form the basis for studies assessing the clinical impact of TCM complication detection and goal-directed-therapy, we examined the association between clinical interventions in the postoperative period and changes in transcutaneous blood gasses.MethodsTwo-hundred adult patients who have had major surgery were enrolled prospectively and monitored with transcutaneous blood gas measurements (oxygen (TcPO2) and carbon dioxide (TcPCO2)) for 2 h in the post anaesthesia care unit, with recording of all clinical interventions. The primary outcome was changes in TcPO2, secondarily TcPCO2, from 5 min before a clinical intervention versus 5 min after, analysed with paired t-test.ResultsData from 190 patients with 686 interventions were analysed. During clinical interventions, a mean change in TcPO2 of 0.99 mmHg (95% CI-1.79-0.2, p = 0.015) and TcPCO2 of-0.67 mmHg (95% CI 0.36-0.98, p < 0.001) was detected.ConclusionClinical interventions resulted in significant changes in transcutaneous oxygen and carbon dioxide. These findings suggest future studies to assess the clinical value of changes in transcutaneous PO2 and PCO2 in a postoperative setting.Trial RegistryClinical trial number: NCT04735380.Clinical Trial Registryhttps://clinicaltrials.gov/ct2/show/NCT04735380.© 2023. The Author(s), under exclusive licence to Springer Nature B.V.

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