• Am. J. Chin. Med. · Jan 2023

    Review

    Research Progress of Traditional Chinese Medicine Monomers in Reversing Multidrug Resistance of Breast Cancer.

    • Shuya Wang, Shuangyu Yang, Xiaojia Yang, Dan Deng, Jie Li, and Mingqing Dong.
    • Cancer Prevention and Treatment Institute of Chengdu, Center for Medicine Research and Translation, Chengdu Fifth People's Hospital/The Second Clinical Medical College, The Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 611137, P. R. China.
    • Am. J. Chin. Med. 2023 Jan 1; 51 (3): 575594575-594.

    AbstractBreast cancer is a malignant disease with an increasing incidence. Chemotherapy is still an important means for breast cancer treatment, but multidrug resistance (MDR) greatly limits its clinical application. Therefore, the high-efficiency MDR reversal agents are urgently needed. Traditional Chinese medicine (TCM) monomers have unique advantages in reversing chemotherapeutic MDR because of its low toxicity, high efficiency, and ability to impact multiple targets. This review firstly summarizes the major mechanisms of MDR in breast cancer, including the reduced accumulation of intracellular chemotherapeutic drugs, the promoted inactivation of intracellular chemotherapeutic drugs, and the enhanced damage repair ability of DNA, etc., and secondly highlights the research progress of 15 kinds of TCM monomers, including curcumin, resveratrol, emodin, apigenin, tetrandrine, gambogic acid, matrine, paeonol, schisandrin B, [Formula: see text]-elemene, astragaloside IV, berberine, puerarin, tanshinone IIA, and quercetin, in reversing MDR of breast cancer. This review also provides the suggestion for the future research of MDR reversal agents in breast cancer.

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