• Medicina · Jan 2023

    COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People.

    • Jannis Kountouras, Maria Tzitiridou-Chatzopoulou, Apostolis Papaefthymiou, Dimitrios Chatzopoulos, and Michael Doulberis.
    • Second Medical Clinic, School of Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
    • Medicina (Kaunas). 2023 Jan 19; 59 (2).

    AbstractThe frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. "Inflame-ageing" and "immune-senescence" are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory cascade. The abovementioned population, although very important from immunologic perspective, has barely been included in the mRNA vaccination clinical trials.

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