• Marcello Chiocchi, Armando Ugo Cavallo, Luca Pugliese, Matteo Cesareni, Daniela Pasquali, Giacomo Accardo, Vincenzo De Stasio, Luigi Spiritigliozzi, Leonardo Benelli, Francesca D'Errico, Cecilia Cerimele, Roberto Floris, Francesco Garaci, and Carlo Di Donna.
• Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.
• Medicina (Kaunas). 2023 Jan 26; 59 (2).

AbstractBackground and objectives: Epicardial adipose tissue density (EAD) has been associated with coronary arteries calcium score, a higher load of coronary artery disease (CAD) and plaque vulnerability. This effect can be related to endocrine and paracrine effect of molecules produced by epicardial adipose tissue (EAT), that may influence myocardial contractility. Using coronary computed tomography angiography (CCT) the evaluation of EAD is possible in basal scans. The aim of the study is to investigate possible associations between EAD and cardiac function. Material and Methods: 93 consecutive patients undergoing CCT without and with contrast medium for known or suspected coronary CAD were evaluated. EAD was measured on basal scans, at the level of the coronary ostia, the lateral free wall of the left ventricle, at the level of the cardiac apex, and at the origin of the posterior interventricular artery. Cardiac function was evaluated in post-contrast CT scans in order to calculate ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), and stroke volume (SV). Results: A statistically significant positive correlation between EAD and ejection fraction (r = 0.29, p-value < 0.01) was found. Additionally, a statistically significant negative correlation between EAD and ESV (r = -0.25, p-value < 0.01) was present. Conclusion: EAD could be considered a new risk factor associated with reduced cardiac function. The evaluation of this parameter with cardiac CT in patients with low to intermediate cardiovascular risk is possible.

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