• Adorata Elena Coman, Alexandr Ceasovschih, Antoneta Dacia Petroaie, Elena Popa, Cătălina Lionte, Cristina Bologa, Raluca Ecaterina Haliga, Adriana Cosmescu, Ana Maria Slănină, Agnes Iacinta Bacușcă, Victorița Șorodoc, and Laurențiu Șorodoc.
• Preventive Medicine and Interdisciplinarity Department, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.
• Medicina (Kaunas). 2023 Jan 31; 59 (2).

AbstractMagnesium is the fourth most common mineral in the human body and the second richest intracellular cation. This element is necessary for many physiological reactions, especially in the cardiovascular and respiratory systems. COVID-19 is an infectious disease caused by SARS-CoV-2. The majority of people who become ill as a result of COVID-19 have mild-to-moderate symptoms and recover without specific treatment. Moreover, there are people who develop severe forms of COVID-19, which require highly specialized medical assistance. Magnesium deficiency may play a role in the pathophysiology of infection with SARS-CoV-2. The primary manifestation of COVID-19 remains respiratory, but the virus can spread to other organs and tissues, complicating the clinical picture and culminating in multiorgan failure. The key mechanisms involved in the disease include direct viral cytotoxicity, endothelial dysfunction, and exaggerated release of inflammatory cytokines. The aim of this review was to summarize the available data regarding the role of magnesium in COVID-19 patients and its particularities in different clinical settings.

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