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- Toshihide Izumida, Teruhiko Imamura, Shuhei Tanaka, Shuji Joho, and Koichiro Kinugawa.
- Second Department of Medicine, University of Toyama, Toyama 930-0194, Japan.
- Medicina (Kaunas). 2023 Feb 18; 59 (2).
AbstractCombined cases of hypertrophic obstructive cardiomyopathy (HOCM) and pulmonary arterial hypertension (PAH) are rare and have a management dilemma. Although preload is crucial in the management of HOCM, anti-PAH agents dramatically change the preload, leading to improving or worsening heart failure in patients with HOCM. We had a 74-year-old woman with Sjogren-syndrome-associated PAH. Her heart failure worsened following the initiation of anti-PAH agents due to an incremental preload on the left ventricle, whereas HOCM clinically developed following the termination of anti-PAH agents and progressing anorexia due to the progression of the left ventricular outflow obstruction. Careful monitoring of the left ventricular outflow obstruction during initiation/termination of anti-PAH agents and medical intervention to the HOCM are highly recommended.
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