• Internal medicine · May 2023

    Case Reports

    Anti-myelin Oligodendrocyte Glycoprotein Antibody-positive Myelitis after Coronavirus Disease 2019.

    • Kenji Uchino, Kaima Soga, Kensuke Shinohara, Takeshi Imai, Iori Motohashi, Hirohisa Okuma, and Yoshihisa Yamano.
    • Department of Neurology, Kawasaki Municipal Tama Hospital, Japan.
    • Intern. Med. 2023 May 15; 62 (10): 153115351531-1535.

    AbstractWe herein report a case of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-related myelitis caused by coronavirus disease (COVID-19) infection in 2021. A 22-year-old man with no history of any related illness contracted COVID-19. Eight days later, he developed bladder problems, paraplegia and sensory disturbances. Cervical spinal cord magnetic resonance imaging revealed extensive hyperintensity at T2 and spinal cord lesions extending from C4 to Th1. The patient was diagnosed with transverse myelitis and started on intravenous methylprednisolone, plasma exchange and intravenous immunoglobulin therapy. The symptoms improved only after intravenous methylprednisolone therapy. Anti-MOG antibodies were found in his serum and cerebrospinal fluid during routine screening. As this observation is unusual and could cause serious health problems, we wonder if COVID-19 triggered this autoimmune response.

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